Free Ebook BookChemical Synthesis of Nucleoside Analogues

Download Ebook Chemical Synthesis of Nucleoside Analogues

Download Ebook Chemical Synthesis of Nucleoside Analogues

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Compiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including: Changes to the heterocyclic base Modification of substituents at the sugar ring Replacement of the furanose ring by a different carbo- or heterocyclic ring Introduction of conformational restrictions Synthesis of enantiomers Preparation of hydrolitically stable C-nucleosides Chemical Synthesis of Nucleoside Analogues covers all the major classes of nucleosides, including pronucleotides, C-nucleosides, carbanucleosides, and PNA monomers which have shown great promise as starting points for the synthesis of nucleoside analogues. The book also includes experimental procedures for key reactions related to the synthesis of nucleoside analogues, providing a valuable tool for the preparation of a number of different compounds. Throughout the book, chemical schemes and figures help readers better understand the chemical structures of nucleoside analogues and the methods used to synthesize them. Extensive references serve as a gateway to the growing body of original research studies and reviews in the field. Synthetically modified nucleosides have proven their value as therapeutic drugs, in particular as antiviral and antitumor agents. However, many of these nucleoside analogues have undesirable side effects. With Chemical Synthesis of Nucleoside Analogues as their guide, researchers have a new tool for synthesizing a new generation of nucleoside analogues that can be used as therapeutic drugs with fewer unwanted side effects. Solid-phase oligonucleotide synthesis - ATDBio All oligonucleotides are made by phosphoramidite solid-phase synthesis. The steps in solid phase synthesis and the preparation of reagents. ... Detritylation of the support-bound 3-nucleoside. At the beginning of ... Adenosine triphosphate - Wikipedia Adenosine triphosphate (ATP) is a nucleotide also called a nucleoside triphosphate is a small molecule used in cells as a coenzyme. It is often referred to as the "molecular unit of currency" of intracellular ... Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for ... Original Article. Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for Hepatitis C. Edward J. Gane M.D. Catherine A. Stedman M.B. Ch.B. Ph.D. Robert H. Hyland D.Phil. Xiao Ding Ph.D. Evguenia ... Modern Organic Synthesis with -Diazocarbonyl Compounds - Chemical ... Alan Ford was born in Gateshead England in 1972. He studied at the University of Hull England and received a B.Sc. in chemistry in 1993 and a Ph.D. in 1996. He has held postdoctoral positions in the Selective ... DNA Modifiers CPR Click Chemistry OPC Glen Research Glen Research RNA and DNA Synthesis Reagents and Phosphoramidite Monomers and Supports for Synthesis Modification and Labelling of Oligonucleotides ... Terminus Modifiers (Part 3) The disulfide thiol modifier may be ... Nucleic acid structure - ATDBio The structure of chemical structure of DNA and RNA; Nucleosides and nucleotides; A-DNA B-DNA and Z-DNA. ... The nucleosides in the DNA duplex adopt the anti conformation (there are very few exceptions to this rule ... Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide ... Citation data is made available by participants in CrossRef's Cited-by Linking service. For a more comprehensive list of citations to this article users are ... Nucleotide - Wikipedia A nucleotide is composed of three distinctive chemical sub-units: a five-carbon sugar molecule a nitrogenous basewhich two together are called a nucleosideand one phosphate group.
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